The Romanian centre-back is suffering from stiffness in his lower back while his Brazilian team-mate has been forced to remain in North London with a virusVlad Chiriches and midfielder Sandro have been withdrawn from Tottenham's tour of the USA and Canada due injury and illness respectively.
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He joins Sandro in being absent for the pre-season fixtures as the Brazilian midfielder has been suffering with a virus and will remain in England.
"Vlad has been complaining of stiffness in his lower back and is continuing to be assessed to determine the extent of the problem," read a statement on Spurs' official website.
"Sandro is recovering from a virus and has been kept behind on medical advice to avoid the risk of spreading the infection."
Meanwhile, Spurs midfielder Alex Pritchard has signed a new deal keeping him under contract at White Hart Lane until 2016.
The 21-year-old has joined Championship newcomers Brentford on loan until the end of the season.