The Germany international returns to face his former club at the RheinEnergie Stadion, with captain Robin van Persie and Alex Song among the substitutes for the Gunners
Lukas Podolski will operate up front for the Gunners against his former club, with fellow new signings Santi Cazorla and Olivier Giroud also starting, whilst England younster Alex Oxlade-Chamberlain lines up in midfield.
Wantaway captain Robin Van Persie is named among the substitutes, and looks likely to come on if, as expected, wholesale changes are made at half-time.
Rumoured Barcelona target Alex Song is also on the subs bench for the Gunners, along with Euro 2012 representatives Laurent Koscielny, Wojciech Szczesny and Andrei Arshavin - who ended last season on loan at Russian side Zenit.
Arsenal: Mannone; Yennaris, Mertesacker, Vermaelen, Gibbs; Coquelin, Oxlade-Chamberlain, Cazorla; Podolski, Giroud, Walcott. Subs: Szczesny, Diaby, Koscielny, Van Persie, Santos, Song, Djourou, Arshavin, Jenkinson, Gervinho, Chamakh, Gnabry.
Koln: Horn, Kubler, Pezzoni, Hector, Strobl, Ishak, Jajalo, Przybylkp, Royer, Wimmer, Schnellhardt. Subs: Schuhen, Eichner, Matuschyk, Tese, Thelen, Broker, Bisanovic, Lehmann.