Argentine pair are joined by fellow first-teamers Kompany, Zabaleta and the Toure brothers while Theo Walcott, Mikel Arteta and Alex Song start for the Gunners in Beijing
City captain Vincent Kompany and Yaya Toure are also included in a strong-looking line up as Roberto Mancini looks to lay down a marker against their Premier League rivals at the Bird's Nest Stadium.
Arsene Wenger confirmed before the game that his side would feature a blend of young players and established stars and Theo Walcott is set to play as the team's central striker, supported by Gervinho and Kieran Gibbs.
Abou Diaby continues his recovery from injury in midfield alongside Alex Song while Thomas Vermaelen will partner Kyle Bartley in the heart of defence.
Manchester City: Pantillimon; Savic, Kompany, Kolo Toure, Kolarov; Zabaleta, Yaya-Toure, Razak, Biton; Aguero, Tevez.
Arsenal: Fabianski; Jenkinson, Vermaelen, Bartley, Santos; Song, Diaby; Gervinho, Arteta, Gibbs; Walcott.