The Cottagers and the south-coast Premier League newcomers both savoured emphatic victories as they continue their preparations ahead of the new domestic season
Fulham won their second pre-season game in emphatic fashion as two goals from Marcello Trotta inspired them to a 4-0 win over Lokomotiv Leipzig.
Cottagers boss Martin Jol opted for an experimental line-up, combining seasoned pros such as Aaron Hughes and John Arne Riise with Trotta and a number of other youngsters.
Fulham made a bright start to proceedings and nearly took the lead nine minutes in when Swedish midfielder Alexander Kacaniklic forced a strong save from Leipzig keeper Christopher Gang.
It didn't take long for the Cottagers to seize the initiative however, as Mesca combined with on-loan Koln defender Sascha Riether to send Trotta through, who slotted in from close range. The 19-year-old Italian quickly doubled Fulham's lead, latching on to Kacaniklic's corner eight minutes before the break.
Jol made a host of changes at half-time with Brede Hangeland, Simon Davies and Moussa Dembele all introduced to the fray. However, the introductions did not upset the Cottagers' momentum and they added a third midway through the second half when Croatian forward Mladen Petric rounded Gang after latching on to a Kerim Frei pass.
The win was completed when Mamadou Diarra nodded Davies' cross into the path Finnish striker Lauri Dalla Valle, who turned the ball home to round off a strong performance.
Southampton continued their pre-season preparations with a comfortable 4-1 over Swiss Side Etoile Carouge.
Adam Lallana, Jason Puncheon and Rickie Lambert were all involved as Saints boss Nigel Adkins named a strong side for the trip to Geneva.
The Premier League new-boys made an impressive start and had the ball in the net after 28 minutes, however, James Ward-Prowse's effort was ruled offside.
And Adkins' men went behind against the run of play 10 minutes later when Dutch defender Jos Hooiveld turned Marco Delley's cross into his own net.
Despite the setback, Adkins stuck to the rotation policy that is the norm in pre-season games, and made nine changes during the break.
It was the introduction of striker Billy Sharp that proved to be instrumental, the former Doncaster man netting a second-half hat-trick as the Saints roused themselves to secure an easy victory.
Young left-back Luke Shaw started the comeback when he combined with Calum Chambers to level matters nine minutes into the second half.
Just over 15 minutes later and the men from the South Coast were ahead as Sharp swept Ward-Prowse's clever free kick past Etoile keeper Sebastien Roth.