The Reds will start their pre-season exploits against the Canadian side, followed by games against Serie A side Roma and Premier League rivals Tottenham ahead of the new season
Liverpool have announced that they will kick-off their summer tour of North America with a friendly against MLS side Toronto FC on July 21.
The game will take place at the Rogers Centre, the 47,000-capacity home of the Toronto Blue Jays baseball team.
The Reds are also scheduled to take on AS Roma at the Boston Red Sox's Fenway Park on July 25 as part of the baseball team's 100th anniversary, followed by a game against Premier League rivals Tottenham in Baltimore on July 28.
Liverpool managing director Ian Ayre told the club's official website: "We're delighted to be opening our North American tour in Canada with a game against Toronto FC.
"With the three games we now have scheduled in Toronto, Boston and Baltimore, we hope that as many of our supporters as possible will have the chance to see the team in action."
Reds manager Kenny Dalglish added: "We're really looking forward to the tour and playing against some quality opposition.
"We had a great time playing in front of our supporters in Asia last year and it will be good to give our fans in North America the chance to watch us this summer.
"I'm told football is the fastest growing sport in North America so hopefully we can put on three good performances for the fans who turn up to watch us play."