The record-breaking goalkeeper turned to the official behind the goal and asked for the full-time whistle out of courtesy to Cesare Prandelli's defeated side
The Azzurri were forced to play the last 33 minutes of the match with 10 men after Thiago Motta limped off due to injury and Spain cruised into a 4-0 lead before injury time started.
During the final minutes, Casillas turned to the additional assistant referee behind his goal and called for an end to the game, stating: "Respect for the rival. Respect for Italy."
The Real Madrid goalkeeper ensured he shook the hand of the official behind the goal as well as the hands of the opposition when the match was concluded before belatedly joining his team-mates up-field for the on-pitch celebrations.
Casillas set a new record of 509 minutes without conceding a goal at a European Championship, as well as becoming the first player to earn 100 international wins, as Spain claimed their third consecutive major title.