With Alvaro Arbeloa and Jordi Alba both on yellow cards, there is a danger that the reigning European champions could be short on defensive options in the quarter-finals
Alvaro Arbeloa and Jordi Alba are both on one yellow card apiece, meaning they are running the risk of being suspended for the quarter-finals should La Roja progress.
However, Del Bosque insists that losing either to a one-game ban would not be catastrophic given the strength in depth he has available to him.
"We would play with three centre-backs or we would send a central defender to play on the left, or use Pedro," the former Real Madrid boss told Cadena SER. "We have plenty of solutions which offer guarantees."
It has been suggested that Spain could rest some players against Croatia given they need only a draw to reach the knockout stages, but Del Bosque insists that he is treating the game like a final.
"We have people in the squad who want to play and would have no problem at all if they were to come in," he stated. "But at the moment I won't 'preserve' any of my players.
"We are playing a final. And if we get to the quarter-finals, there will be another."
Del Bosque has agreed a new two-year contract with the reigning world and European champions and explained that there was never any danger of him leaving his post.
"It was already done; it just needed the formality of the signature," he revealed. "But Monday and the short term is more important [than looking ahead to the 2014 World Cup]."