The 40-year-old took charge of both the Champions League & World Cup finals in 2010, and is now set to officiate during next summer's tournament in Poland & Ukraine
The 40-year-old was England's representative at the Euro 2008 finals, and has since gone on to officiate some of the biggest games in world football.
Webb took charge of Inter Milan's 2010 Champions League victory over Bayern Munich, before refereeing the World Cup final between Spain and Holland two months later - sending off Everton's John Heitinga during the clash.
Scottish referee Craig Thompson has also been named among the 12 officials.
For the first time in the history of the European Championship, four additional officials have been appointed as assistants, to allow the continuation of the experiment in the use of extra referees.
Here is the list of the main officials at Euro 2012:
Cuneyt Cakir (Turkey)
Jonas Eriksson (Sweden)
Viktor Kassai (Hungary)
Bjorn Kuipers (Netherlands)
Stephane Lannoy (France)
Pedro Proenca (Portugal)
Nicola Rizzoli (Italy)
Damir Skomina (Slovenia)
Wolfgang Stark (Germany)
Craig Thomson (Scotland)
Carlos Velasco Carballo (Spain)
Howard Webb (England)
Uefa has named Marcin Borski (Poland), Tom Harald Hagen (Norway), Pavel Kralovec (Czech Republic), and Viktor Shvetsov (Ukraine) as the additional assistant referees at the tournament.
Euro 2012 kicks off on June 8 with the match between Poland and Greece.