Creative midfield pair return to action for DFB team's final competitive match of the calendar year for Joachim Low's side in Dusseldorf
The midfield pair missed out on Friday's 3-1 win over Turkey, with Ozil nursing an ankle injury, and Kroos sidelined due to illness.
However, they have been given the all-clear to start, and will replace Bastian Schweinsteiger and Mario Gotze, who along with the injured Miroslav Klose have been left out of the squad altogether.
Low has made three further tactical changes to his line-up, with Benedikt Howedes replacing Jerome Boateng at right-back, and Mats Hummels replacing Holger Badstuber in central defence. Additionally, Andre Schurrle replaces Lukas Podolski on the left wing.
Belgium coach Georges Leekens has also augmented his previous line-up, which secured a 4-1 win over Kazakhstan on Friday. Striker Igor de Camargo was dropped due to injury, and will be replaced by Marvin Ogunjimi.
In midfield, Marouane Fellaini replaces Dries Mertens, and at the back, Nicolas Lombaerts has been called in to deputise for Daniel Van Buyten.
Germany (4-1-4-1): Neuer; Howedes, Mertesacker, Hummels, Lahm; Khedira; Muller, Ozil, Kroos, Schurrle; Gomez
Subs: Zieler, Rolfes, Aogo, Cacau, Trasch, Gundogan, Reus
Belgium (4-1-4-1): Mignolet; Ciman, Vertonghen, Kompany, Lombaerts; Simons; Hazard, Witsel, Fellaini, Dembele; Ogunjimi
Subs: Courtois, Hoefkens, Defour, Mudingayi, Pocognoli, Mertens, Lukaku