The two sides face off on Saturday, and the Gunners will be looking to end the hosts' stunning home record, which has seen them average over four goals per game
Manuel Pellegrini's men have won all seven of their Premier League home matches this term, scoring 29 goals, but that has not stopped 41.3 per cent of readers from backing Arsene Wenger's charges to secure victory.
The table-topping north Londoners can move nine points above City with a win, and Arsene Wenger has promised that his side will be firing on "full cylinders" as they bid to maintain their advantage at the summit of the table.
The Gunners have had just two full days of rest after their trip to Naples, where they suffered a 2-0 defeat against Napoli in the Champions League, while City have been afforded 24 hours extra preparation.
Despite the possibility of the home side having a physical advantage, 61.9% of readers are convinced that Arsenal will leave the Etihad with at least a point.
City picked up a shock 3-2 win over Bayern Munich on Tuesday night, with James Milner influential as the side rallied from two goals down, but readers believes they are marginally less likely to win the match, with 38.2% backing Pellegrini's men.
The Etihad outfit can move to within three points of Arsenal with a win, and they will be hoping their stunning home form - which has seen them score more goals and concede fewer than any other side - can carry them to victory.