The midfielder believes that his Argentine team-mate would be wrong to consider his future and hopes that the forward stays in Catalonia for the rest of his career
The Argentina star has cut a frustrated figure at times this season and produced several underwhelming displays as the Blaugrana's campaign has stuttered in recent weeks.
Reports have even suggested that Messi could be tempted to seek a move elsewhere as a result of his unhappiness with his current contract but Iniesta has warned his team-mate against making a hasty decision.
He told Sport: "The club will never have a player like Messi but Messi will also never find a club like Barca. I therefore hope that he ends his career at Barca."
The reigning Primera Division champions lost to Atletico Madrid in the Champions League quarter-finals before being beaten by Real Madrid in the final of the Copa del Rey.
The club's quest to retain their league title is also now out of their hands, as they trail the two Madrid clubs in the table, but Iniesta says that their footballing philosophy must remain the same.
"Style is non-negotiable," he remarked, "but you can make changes. The league is very difficult because it does not depend on us but it is not impossible."