The Atletico Madrid coach is hoping that the Blaugrana's big-name forwards both feature at Camp Nou on Wednesday as his side aim to seize the Supercopa in glorious fashion
The Argentina international has been named in the squad for the visit of los Rojiblancos after shrugging off a thigh injury but it is unclear whether the 26-year-old will be handed a starting berth, having sat out Sunday's trip to Malaga.
Neymar is yet to start a competitive fixture for the Blaugrana since his €57 million (£49.1m) move to Camp Nou but, although such a pairing would make life more difficult for his side, Simeone says that he wants to see them both in tandem for the "spectacle" that it would provide.
He told a press conference: "I hope Messi and Neymar both play, for the good of the spectacle, but they have a lot of good players and it's the coach who will decide."
Both teams played out a 1-1 draw in the first game of the two-legged affair but the Argentine coach would not be adverse to the proposal of Spain's governing body altering the format to be played over one leg.
He added: "The tie is wide open but, playing at home and with their characteristics, they'll take the lead role.
"I would like it if the Supercopa were played over one leg sometime in the future."