The Blaugrana announced on Monday that their recovering coach was set to depart America and he has now arrived in Catalunya to resume his work
The 44-year-old went under the knife on December 20, and then underwent chemotherapy and radiotherapy for six weeks.
Vilanova left for New York for further treatment in January, and has now returned home again after two months in the USA.
Pep Guardiola's former assistant took charge of Barcelona in the summer of 2012 after his mentor decided to leave the club and take a one-year sabbatical, and guided the Blaugrana to their best-ever Liga start before being struck by health issues late in 2012.
Vilanova was replaced by Jordi Roura during his absence, with the latter now returning to his role as assistant coach once more.