The Balearic Island outfit have been on a good run of form of late with two wins on the trot, but Jose Mourinho's side have improved of late too and last weekend climbed to second place in the Primera Division.
Despite his side being involved in a fight for survival at the bottom of the table, Manzano still insists that his players can continue their winning streak - though he is aware that it will not be easy.
“Yes it is a shame to face them after winning two in a row, but it is what it is. It is true that the good feelings at the club need to be continued,” Manzano told AS.
“We all know who the favourite is, but we have to stay until the end with the positive feelings from the last games.
“If we do this, the team will grow. Although the game is of the greatest difficulty, after this there are 10 more, but let’s play this one and see what happens.
“Now we go on to the field with a different mentality, we think we can beat anyone, and so we have to do so again against Madrid.
“In football, nothing is impossible and, although the differences are great, in 90 minutes we can provide a surprise. One hopes that Madrid do not have a perfect day”.
The first meeting between the two sides in La Liga, back in October, ended in a 5-0 win to Madrid at the Iberostar Stadium.