The former Valencia striker has been on the fringes of the first team recently, but makes up the attacking forward trio alongside Lionel Messi and Alexis Sanchez, who makes a rare appearance from the off.
With the Champions League on the horizon for the Blaugrana, several first-team players have been rested. Sergio Busquets, Cesc Fabregas, Pedro, and Dani Alves all settle for a place on the bench.
With Xavi injured, Alex Song and Thiago Alcantara partner Andres Iniesta in midfield. Club captain Carles Puyol returns to the first XI and partners Gerard Pique at the back.
Getafe have been boosted by the returns of Miguel Torres and Alberto Lopo, who make the starting XI after serving bans. Pedro Leon has recovered from his knee injury, but can only make the bench.
Diego Castro, Jaime Gavilan, and Abdel Barrada support Adrian Colunga up top.Barcelona (4-3-3): Valdes; Adriano, Pique, Puyol, Alba; Thiago, Song, Iniesta; Alexis, Messi, Villa
Subs: Pinto, Alves, Mascherano, Busquets, Cesc, Pedro, Tello
Getafe (4-2-3-1): Codina; Miguel Torres, Alexis, Lopo, Escudero; Lacen, Borja; Barrada, Castro, Gavilan; Colunga