Los Blancos have made a number of changes for their must-win meeting with the Galicians, with Sami Khedira, Raphael Varane and Gonzalo Higuain among those recalled
Mesut Ozil is recalled and that sees Luka Modric drop into defensive midfield to play alongside the returning Sami Khedira, as Alonso and Michael Essien are both removed from the starting XI.
Elsewhere, Sergio Ramos moves out to right-back to accomodate Raphael Varane at centre-half, with Alvaro Arbeloa the man to make way for his international team-mate.
Up front, Gonzalo Higuain is chosen to start ahead of Benzema, despite the French striker scoring during Madrid's 2-0 win over Rayo Vallecano on Monday night.
Meanwhile, Deportivo boss Jose Luis Oltra has also made changes, one of which is enforced, with Ze Castro replacing Aythami in the centre of defence, after the latter picked up a knock in training during the week.
Alex Bergantinos also comes in to the Deportivo midfield in place of Jesus Vazquez, while Oltra has opted to rest Juan Valeron for tonight's match, and has picked Pizzi to start ahead of the veteran attacking midfielder. Riki retains his place in attack for the away side, with on-loan striker Nelson Oliveira restricted to a place on the bench.
Real Madrid (4-2-3-1): Casillas; Ramos, Varane, Pepe, Marcelo; Modric, Khedira; Di Maria, Ozil, Ronaldo; Higuain.
Deportivo (4-2-3-1): Aranzubia; Manuel Pablo, Ze Castro, Marchena, Evaldo; Bergantinos, Dominguez; Pizzi, Aguilar, Gama; Riki.