The 66-year-old has given his endorsement to the new man at the helm of the Catalan giants, but insists it will be very tough to be as successful as his predecessor.
"I like Tito Vilanova, but, I think it will be difficult for him to repeat what Pep did," said Sacchi in an interview with Esports COPE.
"Going after a coach like Guardiola is very complicated."
Sacchi then went on to talk about a number of players who have been on the move in this summer's transfer window, including Bojan Krkic who has just signed with AC Milan.
"I hope things go well for him at Milan. For both his sake and the team's," he continued.
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"He started as one of the most promising young players, but then he lost his way a little. Hopefully he can get his career back on track with the Rossoneri.
"At Barcelona, after failing to adapt, he was moved on to Roma. I have confidence in him and think that at Milan he can succeed."
A one-time sporting director at Real Madrid, Sacchi also gaves his views on the capital side's latest signing, Luka Modric.
"He is a great signing for Madrid. He is very much a modern footballer, good both on and off the ball. I really like him," he said.
While he praised Real's latest acquisition, he questioned Barcelona's signing of Alex Song.
"He [Song] is a very good player, but Barca already have Busquets and Mascherano who can play in the same position, so I am not sure about this signing."
The former Italy boss then concluded with some thoughts on the departure of Zlatan Ibrahimovic and Thiago Silva from Milan this summer.
"It is clear that Milan have lost important players," he said. "In recent years the team has been planned around the strength of these two players.
"Now they have lost them both, the side will have to play more like a team, without focusing on the particular strengths of a certain few. Allegri has much work ahead of him."