The 26-year-old has never featured at club level in his country of birth, instead first being a part of River Plate's youth programme in Argentina before moving to Europe in 2009 to join Porto.
Now back in Colombia's second largest city of Medellin as part of Los Rojiblancos' pre-season preparations, Falcao is relishing the prospect of putting on a spectacle in front of his countrymen.
"I am very happy and excited to be back in my homeland," the forward told reporters. "I know it will be something unique to play in Medellin.
"It will also be a great responsibility, a chance to return all the support I was given in joys and triumphs. We will do our best to put on a show for the fans of Nacional."
Falcao's former Porto team-mate, Cristian Rodriguez, is expected to make his Atletico Madrid debut during the upcoming match.
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