Fabio Coentrao and Angel Di Maria start for Real Madrid against Atletico in Wednesday's derby at the Vicente Calderon, but Mesut Ozil and Gonzalo Higuain have to make do with a place on the bench.
Coentrao is preferred to Marcelo in defence, while Di Maria starts alongside Kaka and Cristiano Ronaldo in a line of three forwards behind lone striker Karim Benzema.
For Atletico, forwards Adrian and Radamel Falcao had been doubtful with flu, but both start the derby in a stong line-up for Diego Simeone's side.
Madrid are just one point ahead of Barcelona, who thrashed Getafe 4-0 on Tuesday, in La Liga but will look to restore their advantage to four units with victory at the Calderon.
Atletico Madrid (4-2-3-1): Courtois; Juanfran, Perea, Godin, Filipe Luis; Gabi, Tiago; Diego, Arda Tura, Adrian; Falcao
Subs: Asenjo, Dominguez, Assuncao, Fran Merida, Pizzi, Koke, Pedro
Real Madrid (4-2-3-1): Casillas; Arbeloa, Ramos, Pepe, Coentrao; Xabi Alonso, Khedira; Kaka, Di Maria, Cristiano Ronaldo; Benzema
Subs: Adan, Varane, Albiol, Granero, Ozil, Callejon, Higuain