The Argentine forward has been in sublime form in the 2011-12 campaign, and broke yet another record after scoring in the Blaugrana's Primera Division win over Getafe
The record was previously held by former Athletic Bilbao striker Telmo Zarra and ex-Atletico Madrid star Baltazar, who both netted 27 goals in home league games in 1950-51 and 1988-89 respectively.
Real Madrid attacker Cristiano Ronaldo, who set a new Pichichi record last term with 40 goals in one season, managed to score 26 times at the Santiago Bernabeu in 2010-11.
Messi has scored in all but two of Barcelona's Primera Division games at Camp Nou this term. The Argentine was unable to find the net in the scoreless draw against Sevilla, and didn't feature in the 3-1 win over Sporting Gijon.
The 24-year-old has netted 39 times in 31 appearances this season in La Liga, and needs only more goal in the remainder of the term to equal Cristiano Ronaldo's record of 40 goals in a single league campaign.