The Santiago Bernabeu outfit have received some encouraging news from their treatment table for the cross-town derby as the two regular starters have regained full fitness
The Argentina international has been out of action since sustaining a hamstring injury in his side's 7-1 thrashing of Osasuna earlier in the month, while it has taken Marcelo three weeks to recover from a thigh strain.
Meanwhile, Kaka and Alvaro Arbeloa have both been deemed unfit for the match after failing to train with the rest of the squad in Friday's practice session.
The Brazil midfielder is battling a knee injury, while the Spain international is recovering from a hamstring problem. Ricardo Carvalho, meanwhile, is still nursing a back complaint.
This means that Lassana Diarra is expected to play on the right side of the defence against Atletico, as Sergio Ramos should partner Pepe in the centre of the back line.
Madrid are at the Liga summit, with 31 points from 12 matches, while Atletico sit ninth, on 16 points.