Pep Guardiola brings David Villa into his starting XI while Thiago starts in midfield with Sergio Busquets dropping into the centre of defence in place of Carles Puyol
The former Valencia man replaces Seydou Keita, with Cesc Fabregas dropping back into a three-man midfield, alongside Xavi and Thiago.
Gerard Pique is not risked after overcoming injury and starts the game on the bench with Carles Puyol also named as a substitute.
Pep Guardiola has instead chosen to go with Sergio Busquets and Javier Mascherano as a centre-back partnership.
Atletico Madrid have been boosted by the return of Diego who forms a three-man attack alongside Jose Antonio Reyes and the in-form Falcao.
Barcelona (4-3-3): Valdes; Alves, Busquets, Mascherano, Abidal; Thiago, Xavi, Fabregas; Messi, Pedro, Villa
Subs: Pinto, Fontas, Maxwell, Keita, Adriano, Puyol, Pique
Atletico Madrid (4-3-3): Courtois; Perea, Godin, Miranda, Antonio Lopez; Tiago, Gabi, Suarez; Diego, Reyes, Falcao
Subs: Asenjo, Turan, Adrian, Filipe, Salvio, Dominguez, Juanfran