See how the simulation of the game pans out
Quique Sanchez Flores's side have suffered a relentless winless streak at the hands of the Spanish giants in recent history.
Last time out, Jose Mourinho's men secured a two-legged 4-1 aggregate victory over their rivals in the Copa del Rey, with a single goal from Cristiano Ronaldo in the second leg wrapping up the win.
But Flores believes now is a good time for Atletico to meet their illustious neighbours and is confident of a win to keep their hopes of European qualification alive.
Watch how EA Sports have predicted the game will pan out below, and let us know if you believe their forecast will ring true on Saturday night.