The 28-year-old Brazilian's bid to secure a move to Santos has affected his fitness meaning that he will miss out on the quarter-final tie against the Bianconeri
The Brazilian has been in talks over a proposed move to Santos, and the time spent in negotiations is said to have affected his fitness.
French defender Philippe Mexes will return after missing the win over Siena due to suspension, but the Rossoneri still have a long injury list, including Djamel Mesbah, Christian Abbiati, Kevin Constant, Mario Yepes, Daniele Bonera, Nigel De Jong, Cristian Zapata and Sulley Muntari.
Milan squad in full:
Goalkeepers: Amelia, Coppola, Gabriel.
Defenders: Abate, Acerbi, Antonini, De Sciglio, Mexes.
Midfielders: Ambrosini, Boateng, Carmona, Emanuelson, Flamini, Montolivo, Nocerino, Traore.
Forwards: El Shaarawy, Niang, Pazzini, Bojan.