The Italian faces the club he played for last season before switching allegiances, and will be partnered by the Argentine striker in attack for the Nerazzurri
The Italian striker applied his trade in the red and black of Milan this time last season but was involved in a summer switch that saw Giampaolo Pazzini go the other way, and the former makes the starting XI tonight.
The away side will start with Javier Zanetti and Yuto Nagatomo on the flanks and they will likely be employed as wing-backs.
Massimiliano Allegri has shuffled the pack somewhat and has named Spanish striker Bojan as his lone striker, with a supporting cast of Stephan El Shaarawy, Kevin Prince-Boateng, and Urby Emanuelson playing slightly deeper in attack.
Daniele Bonera has been shifted out to right-back with Mario Yepes coming in to partner Philippe Mexes in the centre of the Milan defence.
AC Milan (4-2-3-1): Abbiati; Bonera, Yepes, Mexes, De Sciglio; De Jong, Montolivo; Emanuelson, Boateng, El Shaarawy; Bojan
Inter (3-4-1-2): Handanovic; Ranocchia, Samuel, Juan; Zanetti, Gargano, Cambiasso, Nagatomo; Coutinho; Milito, Cassano