The former Barcelona forward, who is no stranger to highly charged fixtures given his experience in El Clasico, hopes that he makes the starting line-up against the Nerazzurri.
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"Of course we have to win the derby to make our fans happy and also because we need the three points," the Spanish international said to the club's official TV channel.
"I am very happy to be experiencing the atmosphere of this game directly. Of course I'd love to play in the Milan derby.
"In Europe there are several really big derby matches that everyone pays attention to. The atmosphere in the Rome derby is also wonderful, as the fans start talking about it a month beforehand."
Kick-off at San Siro is at 19:45GMT.