The Italy international left the Blucerchiati on bad terms last year, but while there is no longer any ill feeling between the two parties, there is no chance of an reunion
It had been speculated that the Italy international could be the next big name to depart AC Milan, with Thiago Silva and Zlatan Ibrahimovic both having completed multi-million euro moves to Paris Saint-Germain in recent days.
However, Garrone insisted that there is little chance of Cassano ending up back with the Blucerchiati, with whom the attacker had an infamous falling-out before moving to San Siro during the 2011 January transfer window.
"Cassano is always saying that he would like to return to Sampdoria," Garrone told reporters in Milan on Wednesday. "But he is a Milan player, and on this player, there is no news.
"With Cassano, we experienced many wonderful moments, but in life, roads diverge. It's good that he is at Milan and we are no longer talking of his return to Sampdoria."
Garrone did, however, leave the door slightly ajar for the forward to perhaps rejoin the club at a later date, insisting that there is no longer any bad blood between his father, Riccardo, and the forward.
"Our relationship is great," he explained. "Things are also now okay with my dad; the relationship is back to what it once was.
"However, I repeat, he is an AC Milan player and I can rule out his return to Sampdoria this year."
As Goal.com revealed on Wednesday, it is far more likely that Cassano will end up joining Samp's city rivals Genoa, should he leave Milan this summer.