The Argentine picked up an injury against Fiorentina and missed three matches, while the Brazilian steps up in place of Antonio Cassano, but there is no Thiago Silva
The Argentine has missed three matches after coming off at half-time with an injury in the recent trip to Fiorentina, but starts the fixture having made a full recovery. Ricky Alvarez gets the nod ahead of Mauro Zarate, and is likely to start just behind Diego Milito.
Neighbours Milan make a change up front, recalling Robinho in place of Antonio Cassano, while Daniele Bonera comes in at left-back for the injured Luca Antonini. Thiago Silva remains unavailable six weeks after injuring his hamstring against Roma.
Milan need a victory as they enter the match a point behind Juventus in the Scudetto race, while a victory for Inter will keep them in with a chance of earning a Champions League spot.
Inter (4-3-2-1): Julio Cesar; Maicon, Lucio, Samuel, Nagatomo; Guarin, Cambiasso, Zanetti; Sneijder, Alvarez; Milito.
Subs: Castellazzi, Cordoba, Pazzini, Palombo, Obi, Ranocchia, Zarate
Milan (4-3-1-2): Abbiati; Abate, Nesta, Yepes, Bonera; Nocerino, Van Bommel, Muntari; Boateng; Ibrahimovic, Robinho.
Subs: Amelia, Mexes, Gattuso, Aquilani, Maxi Lopez, De Sciglio, Cassano