The Nerazzurri legend is of the opinion that the Portuguese coach is a big gamble and hopes that Claudio Ranieri stays until the summer
The 34-year-old is believed to be in pole position to take over at Inter if the Nerazzurri decide to part company with under-fire coach Claudio Ranieri.
Villas-Boas, who was sacked by Chelsea on Sunday, was already close to the Inter hot-seat in the summer after guiding Porto to four titles in 2010-11.
But Mazzola, who played at Inter between 1960 and 1977, believes that the Portuguese coach is too much of a gamble for the Nerazzurri.
"He has just been sacked at Chelsea and there must be a reason, right? I do not think he can make a difference," he told Tuttomercatoweb.
"He is very young, he earns a lot, perhaps his agents are good, but personally I would not take him.
"I hope that Ranieri stays until the end of the season, it would mean that Inter would have recovered."