The 52-year-old Italian only took charge of his hometown club in November but Sunday's defeat at home to AC Milan resulted in the club dropping to the bottom of Serie A
The former Cavallucci Marini defender still had just over four months of his contract to run but the club issued a brief statement on their official website on Monday evening announcing that Arrigoni had left the Dino Manuzzi by mutual consent.
The 52-year-old Italian only took charge of his hometown club in November but Sunday's 3-1 defeat at home to Serie A leaders AC Milan, coupled with Novara's draw with Atalanta, resulted in Cesena dropping to last place in the table.
Arrigoni had taken over from Marco Giampaolo, who had only been at the helm for six months.
Cesena, who have lost four of their last five league games, travel to Chievo on Sunday.