More changes suffice for Gian Piero Gasperini, who opts for a different formation, as opposed to the four men at the back that featured in the defeat to Trabzonspor in midweek
Despite seeing his 3-4-3 formation seemingly fail, with two competitive losses in as many matches, the former Genoa tactician has decided to renege on the 4-3-1-2 system that he experimented with midweek and try out a 3-5-2 instead.
As a result of their tactical alterations, right-back Jonathan, and forwards Mauro Zarate and Giampaolo Pazzini have been dropped in favour of Walter Samuel, Diego Milito and Diego Forlan, whilst Wesley Sneijder drops into central midfield.
Meanwhile for Luis Enrique's Roma outfit, only two changes have been made from their disappointing 2-1 defeat to Cagliari last weekend.
Full-back Jose Angel is suspended after picking up a red card against the Sardinians, with Marco Cassetti replacing the Spaniard at left-back. Also, fellow new signing Pablo Osvaldo is dropped from attack, but Marco Borriello starts in place of his Italo-Argentine compatriot tonight.
Fernando Gago, however, continues to be denied of his full Roma debut, after remaining on the substitutes bench, but Simon Kjaer also features in what will be his first appearance in the Roma squad.
Inter (3-5-2): Julio Cesar; Lucio, Samuel, Ranocchia; Obi, Sneijder, Cambiasso, Zanetti, Nagatomo; Milito, Forlan.
Subs: Castellazzi, Jonathan, Muntari, Alvarez, Coutinho, Zarate, Pazzini.
Roma (4-3-3): Stekelenburg, Rosi, Burdisso, Heinze, Cassetti; Perrotta, De Rossi, Pjanic; Bojan, Borriello, Totti.
Subs: Curci, Kjaer, Taddei, Pizarro, Gago, Osvaldo, Borini.