Hamburg captain Rafael van der Vaart has been ruled out for up to three weeks with torn ankle ligaments.
The Netherlands international was taken off after 52 minutes in the 4-2 defeat to Eintracht Braunschweig on Saturday.
In a statement on their official website, Hamburg confirmed that the 31-year-old suffered "torn ligaments in his right ankle" during the fixture.
He will likely miss Bundesliga fixtures against Borussia Dortmund, Werder Bremen and Eintracht Frankfurt, with coach-less Hamburg currently second bottom of the Bundesliga.
The club dispensed of the services of Bert van Marwijk on Saturday after slumping to a seventh straight league defeat at the Eintracht-Stadion.
Former Schalke and Hannover coach Mirko Slomka has been touted as the man to replace Van Marwijk.