The 25-year-old, who will swap clubs to join Schalke in teh summer, has been out of action since picking up a thigh injury in November but expects to feature on Saturday
The Germany international has not played for Sam Hyypia's side since picking up a thigh injury during the 1-0 win over Hertha Berlin in November.
Since then, the 25-year-old has agreed to join Schalke at the end of the season but the former Hamburg forward is fully focused on making his comeback.
"I'm assuming that I'm back in the squad on Saturday," he told Express.
"It looks good again, I have no more pain."
Sam will move to the Veltins Arena at the end of the current campaign, having agreed a deal that will keep him under contract at Schalke until 2018.
He has 11 goals in all competitions this season, helping Leverkusen to second in the table while also qualifying for the Champions League knockout stages.