Sky Italia claimed on Thursday evening that BVB had accepted a €30 million [£25.5m] offer from the Liga runners-up, only for Poland international to turn down the Spanish giants as he only wants to join Bayern Munich.
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|8/1||Robert Lewandowski is 8/1 with BetVictor to join Manchester City this summer
"I can only say that we don't know anything about an alleged Madrid offer for Lewandowski," Watzke told Sport1.
"At the moment, there has not been any contact with Real Madrid about Lewandowski. There have been rumours that Madrid are interested in Robert for a number of weeks now, but he has always been clear that he wants to join Bayern."
Watzke underlined that Lewandowski will not be sold to rivals Bayern Munich, following the club's recent statement, despite the Poland international's claims that BVB promised him he would be allowed to move.
He added: "There will not be a transfer to Bayern this summer."
Lewandowski is under contract with Dortmund until June 2014, but he is desperate to leave the club this summer and following in the footsteps of former team-mate Mario Gotze who has already sealed a switch to the Allianz Arena.