The centre-back was forced to leave the pitch on the 25th minute following a collision with Gonzalo Higuain earlier in the match.
|THREE IN A ROW FOR DORTMUND?|
|6/4||Dortmund are 6/4 to retain the Bundesliga next season|
It is not yet known how long Hummels will be out of action as he has yet to undergo further examination, but the centre-back is doubtful for Borussia Dortmund's DFB-Pokal clash with Oberneuland at the weekend.
Marcel Schmelzer, Ilkay Gundogan, Mario Gotze and Marco Reus also featured for Germany in Wednesday's match, but came out unscathed.
Dortmund opened the 2012-13 campaign with a 2-1 loss against rivals Bayern Munich in last weekend's DFL-Supercup.