Blanc has come under fire following a dismal week which has seen his side exit the Champions League after squandering a 3-1 first-leg advantage against Chelsea and then lose 1-0 at Olympique Lyonnais in Ligue 1.
Going out of European competition was a significant setback for a club bankrolled by the Qatar Investment Authority but Al-Khelaifi insists Blanc is secure in his job.
He told Le Parisien: "I am extremely surprised to read the various reports on our coach.
"It's very simple: he is our coach now and I insist that I want him to stay. I was very clear on that before the return game against Chelsea and my opinion has not changed."
PSG have the chance to avenge their loss to Lyon when they take on les Gones in the Coupe de la Ligue final on Saturday but Al-Khelaifi is adamant even a third straight loss will not alter his stance.
"Laurent Blanc has my unconditional support and anything that happens on the pitch cannot change it," he added.
Blanc is under contract with PSG until the end of next season and the club have already proposed a 12-month extension, which the former France boss is considering.