A long punt up field from Uruguay goalkeeper Fernando Muslera was inadvertently flicked on by captain Steven Gerrard to allow Luis Suarez to score a late winner in a 2-1 defeat
Suarez struck with just five minutes left to give Uruguay a 2-1 win on Thursday, a result that kept their own World Cup hopes alive and virtually ended England's despite Wayne Rooney's earlier equaliser.
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"Very disappointed [to concede that way], obviously, as a defender," Jagielka told ITV. That's the last thing you want to see. As you can tell by my voice, everybody's absolutely devastated in there.
"You just hope [Suarez] misses. He obviously finds the target and they win the game."
Jagielka was also downcast on England's unlikely chances of reaching the last 16, claiming they have a "small chance" and that he was not expecting anything.
He did, however, emphasise the importance of their final Group D match against Costa Rica.
"We've got to go out there and put out a performance against Costa Rica," he continued.