The Arsenal midfielder has been shielded during the club's pre-season following an ankle injury picked up last season, but the 21-year-old is in line to start against Scotland
The 21-year-old has been nursed through the Gunners' pre-season preparations following an ankle injury picked up last season, and a start on Wednesday will be just his second in 26 months for the national side.
Having won his first cap in 2010, the youngster's only start since the 2-2 draw against Switzerland in June 2011 came againt Brazil earlier this year - and Wenger is allowing his star man to feature for the Three Lions after getting through 45 minutes unscathed against Manchester City.
"I decided before the game to only play Jack for 45 minutes because I want to take it step by step," Wenger told reporters.
"Now he goes away with the national team and, when England play Scotland, it is always competitive.
"Jack will go away with England with our blessing. But then we have have some big occasions in front of us, with Aston Villa and also the Champions League."
And Hodgson, whose squad gathered at St George's Park on Sunday night says he's committed to ensuring that the players are kept fit.
"I'm happy that he [Wilshere] is fit and with us," Hodgson said.
"We know he's not going to play for 90 minutes. Arsene knows we’re as anxious to protect the health and fitness of the player as he is.
"I don't want to damage players and there are quite a few of them who haven't really played a lot football in the pre-season or are maybe coming back from injury.
"It is certainly incumbent upon me to take those things into consideration but the feedback from all the managers has been good. They understand the importance of the autumn for all their players, not just the England ones."
Despite being one of the great young hopes for English football, Wilshere has played less than seven hours of football in a Three Lions shirt due to his various injuries.