Paul Cook's men, currently sitting in third place, can leap to the top of the table due to their superior goal difference if they win, while Newport welcome strugglers Northampton
Paul Cook's side - who are third in the standings - visit Cheltenham Town and can return to the summit as second-placed Burton Albion face Bournemouth in the FA Cup, while leaders Scunthorpe United were due to play Bristol Rovers, but their opponents are also in cup action against Crawley Town.
Chesterfield headed into the new year at the top of the league, but they were denied the chance to extend their advantage as their fixture at bottom side Northampton Town on Wednesday was abandoned due to a waterlogged pitch.
They will return to action looking to build on a four-match unbeaten run in the league, although they have suffered a slight blip with consecutive 1-1 draws.
Newport County's fixture with Oxford United also fell victim to the adverse weather on New Year's Day. The Welsh outfit are hopeful of returning to the play-off places in Saturday's showdown with Northampton.
Justin Edinburgh's men suffered a 1-0 setback at high-flyers Burton in their last league outing, and they will be keen to return to winning ways at Rodney Parade.
At the bottom end of the table, Torquay United can move out of the relegation zone as Alan Knill's charges host Morecambe at Plainmoor.
Torquay have endured a torrid season, winning on just five occasions in League Two, and they head into the Morecambe showdown on the back of Wednesday's 2-0 setback at Plymouth Argyle.
Fellow strugglers York City welcome Dagenham and Redbridge to Bootham Crescent, and lie just three points above the relegation zone.
However, Nigel Worthington's men will be boosted by the 1-0 triumph at home to Morecambe, with Ryan Jarvis' first-half strike earning York their first maximum haul since the end of October.
In other matches, two sides battling at the wrong end of the table meet at Fratton Park as Portsmouth welcome Accrington Stanley, while Mansfield Town will look to move away from the danger zone on their visit to Exeter City.
Wycombe Wanderers host an AFC Wimbledon side who are currently in 15th.