The three teams sit in the promotion places, separated by just two points, with York City, Exeter City and Cheltenham Town their opponents for matchday 21
Paul Cook's men head into the latest round of fixtures just one point adrift of leaders Oxford United, who travel to struggling York City on Saturday, and can therefore hit the summit with a win at St James' Park.
Exeter, who sit 11th in the table, will be buoyed by ending a seven-game winless run at Accrington Stanley last time out, but face a Chesterfield outfit who have lost just one of their last eight League Two fixtures.
Any slip-ups from Chesterfield and Oxford could be capitalised upon by Fleetwood Town, who are just two points off the lead in third place.
However, Fleetwood host a Cheltenham Town side who are unbeaten in five away league matches and head to Highbury on Saturday defending a streak of nine games without defeat, not including a cup reversal against Tamworth.
Just two points separate fourth-placed Newport County and Morecambe in ninth, and the former - who are just a point behind Fleetwood - will be confident of racking up a sixth straight home league victory when they entertain AFC Wimbledon.
Seventh will meet eighth when Southend United welcome Rochdale, who are without a win in three, to Roots Hall in Friday's other fixture.
Elsewhere, Scunthorpe United and Burton Albion - placed fifth and sixth with 34 points apiece - play Morecambe and Hartlepool United respectively on Saturday.
At the other end of the table, bottom club Torquay will look to build on a surprise win over Southend last time out at Dagenham and Redbridge.
Torquay will be wary of the threat posed by striker Rhys Murphy - the division's top scorer with 11 goals so far this term.
Second-bottom Northampton Town entertain a Wycombe Wanderers side who are winless in eight league games.
Saturday's other League Two encounters see struggling Bristol Rovers host Portsmouth, Accrington Stanley travel to Mansfield Town and Plymouth Argyle play Bury.