Aidy Boothroyd's men sit bottom of the division with just 10 points from 15 matches, while the visitors lead the way on 28 points after recording back-to-back league victories.
The FA Cup provided some respite last time out for Northampton, who won 2-1 at Conference South side Bishop's Stortford, but their focus on Saturday will switch to the fight for Football League survival.
|LEAGUE TWO FIXTURES
Dag & Red
Despite that revival, which has earned Stanley nine of their 11 points, the Lancashire club remain in the relegation zone ahead of their trip to Scunthorpe United, who sit eighth but are only two points off second.
The unpredictable nature of the league will offer some hope to Northampton and Accrington, with only three of the current top 12 having won their last game, while six bottom-half teams were victorious last time out.
That has created a situation whereby just five points separate the top 11 teams, leaving the likes of Oxford United and Chesterfield, who occupy automatic promotion spots, under severe threat.
Oxford travel to a Mansfield Town side who scored eight in their FA Cup triumph over non-League St Albans City, while Chesterfield, winless in seven league games, make the long trip to take on struggling Torquay United.
Bristol Rovers tackle Bury in a battle between two of the division's bottom-six outfits, although Rovers' victory over Oxford in their last game eased their fears.
Paul Tisdale's Exeter City have fallen out of the top three to sixth following a run of just one victory in five games and they meet Southend United, only a point behind them.
Morecambe versus Rochdale pits fifth versus fourth respectively, while Dagenham and Redbridge, in 11th, can jump above seventh-placed Burton Albion when they host Gary Rowett's men.
Elsewhere on Saturday, Wimbledon play Portsmouth, Cheltenham Town are on the road at Wycombe Wanderers and Plymouth Argyle head to York City.
In Friday's only match, in-form Hartlepool United, with five wins from their last six league games, travel to Newport County.