The leaders will look to build on their midweek triumph over Northampton Town against Dagenham & Redbridge, while their closest rivals aim for their first victory in five gamesLeague Two leaders Rochdale will look to build on their dramatic midweek win over Northampton Town when they travel to Dagenham & Redbridge.
Last-gasp efforts from Michael Rose and George Donnelly saw Keith Hill's men secure a 3-2 win to reach the summit on Tuesday night.
A shaky start against saw some sections of the Rochdale faithful vent their frustration at the team but Hill has warned that such outbursts are not helpful to his side.
"I can’t comprehend one or two narrow-minded fans shouting at me to get my players off the pitch because they’re rubbish," Hill told Dale Player.
"We’ve got to be very careful; confidence is precious. The fans are magnificent but when we’re not quite confident and when we’re not quite on it the players need the support of the fans so much more."
Second-placed Chesterfield are only two points adrift of Rochdale, despite not recording a league win in five attempts.
Paul Cook's side face Bristol Rovers, who are on a miserable run of their own having not tasted victory in the league for eight matches.
There is little room for any mistakes at the top, with only four points separating second from 13th.
Eighth-placed Burton Albion could even leapfrog Exeter City in third with a win at St James' Park, while Newport County host Southend United with both sides knowing victory could give them an early advantage in the race for promotion.
Elsewhere, Oxford United travel to AFC Wimbledon, Mansfield Town host Plymouth Argyle and Morecambe entertain rock-bottom Accrington Stanley, who finally picked up their first win of the season against Bristol Rovers on Tuesday night.
Fleetwood Town, meanwhile, will need to keep York City's Ryan Jarvis quiet at Bootham Crescent if they are to get their promotion bid back on track following successive defeats. The 27-year old has found the net seven times to top the goalscoring charts alongside Dagenham's Rhys Murphy.
Portsmouth will be keen to get back into action at fellow south-coast side Torquay United, after the former's clash with Wycombe Wanderers on Tuesday night was abandoned at half-time due to a waterlogged pitch.
At the same time, Wycombe Wanderers host Bury, while Scunthorpe United welcome Hartlepool United to Glanford Park.
In the weekend's early kick-off, struggling Northampton will look to climb out of the bottom two when they play Cheltenham Town at Sixfields.