Mark Warburton's side leapfrogged Leyton Orient into top spot on Sunday, and will be looking for a seventh win on the bounce when fifth-placed Posh visit Griffin Park
Mark Warburton's side moved to the top of the table with a comfortable 3-1 win over Milton Keynes Dons on Sunday - their 11th victory in their last 12 league fixtures.
And the Griffin Park outfit will feel confident of making it seven wins in a row at fellow promotion hopefuls Peterborough, who are hoping to avoid a third consecutive defeat after losses at Coventry City and Carlisle United.
Leyton Orient and Wolves can both take advantage if Brentford fail to win at London Road. The pair - who are a point behind Orient in second and third - played out a 1-1 draw on Sunday, and will look to get back to winning ways against Bristol City and Tranmere Rovers respectively.
Two prospective promotion challengers do battle at Deepdale as Preston North End host a Port Vale side looking for a third straight win, while Rotherham United will need to be at their best if they are to beat a Coventry team that has scored the most goals in the division this season (49).
At the other end of the table, bottom side Notts County - five points adrift of safety after Sunday's 1-0 defeat to Crawley Town - entertain Bradford City, who are without a win in six league games, while fellow strugglers Stevenage take on Gillingham.
Meanwhile, Crewe Alexandra can move out of the bottom four with a victory over Carlisle.
Steve Davis' men overcame Colchester United to end a three-game winless streak in their last outing, and will look to build on that success against Graham Kavanagh's team, who are five points above the drop zone following their win over Peterborough.
Sheffield United can pull further away from the relegation zone if they secure their third win in five games against Walsall after a 3-1 victory over Tranmere kept the Yorkshire club three points clear of danger.
Elsewhere, Oldham Athletic face Shrewsbury Town in a game between two teams hoping to boost their survival chances, Swindon Town take on Crawley and MK Dons meet Colchester.