Four wins in a row - with no goals conceded in three - have seen the Bees propelled up the table and their Boxing Day opponents have had little luck on the road this season
The London club are riding on the crest of a wave after extending their winning run to four league games with an impressive 3-0 triumph at fellow promotion hopefuls Preston North End on Saturday.
Brentford have secured all three points in nine of their last 10 games in the third tier and have not conceded in their last three matches.
Mark Warburton has won his first two matches since replacing Wigan-bound Uwe Rosler as manager and his side are only a point behind out-of-sorts Leyton Orient and Wolves - who are joint-top of the table. Brentford face a Swindon side on Boxing Day who have only won twice away from home in the league.
Orient suffered a 3-2 home defeat against Crawley Town on Saturday and are now without a win in their last four League One games.
Russell Slade will be determined to get back on track when Orient travel to Gillingham on Saturday but the Kent club will be buoyed by a 2-1 win at Tranmere Rovers at the weekend.
Wolves are now without a win in three but did, at least, avoid a third consecutive defeat with a 3-3 draw at Rotherham United on Saturday. Kenny Jackett's charges will be expected to get the better of struggling Crewe Alexandra at Molineux on Thursday.
Fourth-placed Peterborough United are five points behind the top two after getting the better of Bradford City and next face Coventry City away from home.
Bradford entertain Rotherham in a Yorkshire derby between two sides that have aspirations of securing promotion.
Preston, another side plotting a return to the Championship, go in search of a first win in three League One games at Carlisle United.
Rock-bottom Bristol City were denied three precious points when Notts County defender Alan Sheehan scored a late penalty to secure a 1-1 draw at the weekend and they could really do with a win when Walsall travel to Ashton Gate.
Thursday's other fixtures see MK Dons travel to Crawley, Colchester United host Stevenage, Port Vale entertain Notts County, Sheffield United face Oldham Athletic at Bramall Lane and Tranmere visit Shrewsbury Town.