Russell Slade's side, who travel to Brentford on Monday, are the only club in the English Football League to still have a 100 per cent record
Russell Slade's side will be aiming to preserve the English Football League's only remaining 100 per cent record when they travel to Griffin Park.
They go into the clash full of confidence, having dispatched Notts County 5-1 on Tuesday night, while ninth-placed Brentford's last outing saw them triumph in a 4-3 thriller with Tranmere Rovers.
The chasing pack will have an opportunity to make up ground on the leaders on Saturday, with second-placed Peterborough United hosting Milton Keynes Dons, currently unbeaten and lying in sixth.
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Peterborough, five points behind Orient, are in fine goalscoring form having seen off Bristol City 3-0 at the weekend, where Britt Assombalonga's brace took him to six league goals for the season.
Wolves, behind Peterborough only on goal difference, travel to 13th-placed Shrewsbury Town in the day's early kick-off looking to bounce back after Tuesday's 1-0 home defeat to Walsall, which brought an end to their five-match winning streak.
Walsall moved up to seventh place with that win, outside the play-offs on goal difference, and they face another stern test of their credentials on Saturday when they host fourth-placed Rotherham United.
Steve Evans' side, unbeaten so far this season, have won their last three matches and look comfortable at this level having won promotion from League Two last year.
A place below them in the table and also yet to taste defeat are Preston North End, who travel to struggling Sheffield United on Saturday.
David Weir's side have picked up just four points from the opening seven games and currently find themselves just two places off the bottom.
Their Yorkshire counterparts, Bradford City, have enjoyed a much better start having made the step up following their League Two play-off success in May.
Phil Parkinson's men travel to another promoted side, Gillingham, on Saturday with the hosts struggling to adapt to life in the third tier. They have earned just three draws from their early fixtures.
The other side currently in the relegation zone, Bristol City, travel to 12th-placed Swindon Town having picked up just their fourth point of the campaign on Tuesday with a 1-1 draw at home to Shrewsbury.
Coventry City have now wiped out their 10-point deduction for going into administration, and they will be confident of mounting a charge up the table, starting with Saturday's trip to Port Vale, while rock-bottom Notts County, with just a solitary point to their name, host 17th-placed Tranmere and Stevenage face Carlisle United.
Elsewhere, Oldham Athletic are at home to Crewe Alexandra, while 10th-placed Crawley Town travel to a Colchester United side one place below them.