Leyton Orient will put their unblemished League One record on the line against Port Vale on Saturday.
Russell Slade's side have won all five of their league fixtures this season, earning them a two-point gap over pre-season title favourites Wolves.
They are yet to concede at home in the league, but the visitors, who sit 13th, will arrive with renewed hope having picked up their first points on their travels at the weekend with a 1-0 win at struggling Carlisle United.
Wolves, who are unbeaten and have won their last four games, host 10th-placed Swindon Town, while high-flying Peterborough United travel to Ashton Gate to take on Bristol City after two games without a win.
Sean O'Driscoll's Bristol City were relegated from the Championship last term but have struggled so far in their new surroundings, currently lying 20th after taking just three points from their opening five games.
Two sides promoted from League Two last year, Rotherham United and Bradford City, have enjoyed strong starts to the new campaign and sit fourth and fifth respectively.
Unbeaten Rotherham host Oldham Athletic on Saturday, while Bradford, for whom Nahki Wells has six league goals already this season, will also enjoy home advantage as they take on Colchester United.
Sixth-placed Preston North End, one of five unbeaten sides in the division, face Stevenage at Deepdale, while Milton Keynes Dons, another side yet to taste defeat so far, are at home to bottom club Notts County.
Just above Notts County are the league's top scorers, Coventry City, who wiped out their 10-point deduction with victory over Colchester United on Sunday, and they will hope Callum Wilson, who has eight to his name so far this season, will continue his fine goalscoring form when they host Gillingham at Sixfields on Sunday.
A win for Steven Pressley's side will see them climb above their opponents in the table.
Carlisle, without a win and with the division's worst defensive record, are at home to fellow strugglers Sheffield United.
David Weir's side, who lost in the play-offs last season, have taken just four points from their opening six matches and are yet to pick up a point on their travels.
Crawley Town sit outside the play-off spots on goal difference, and they will be looking to climb into the top six with a home win over lowly Shrewsbury Town.
Elsewhere, ninth-placed Brentford travel to Tranmere Rovers, while Crewe Alexandra host Walsall.