Dave Mooney grabbed a brace for his side as they eased to a 3-0 victory over Shrewsbury, while Darren Ferguson's men won 4-2 at Meadow Lane in a great encounter with Notts County
Dave Mooney was Orient's hero as he scored twice in their 3-0 victory over Shrewsbury at the Matchroom Stadium.
Moses Odubajo added the third goal in the closing minutes of the match to leave them top of the table on goal difference from relegated Peterborough.
Darren Ferguson's side emerged 4-2 victors in a thriller at Meadow Lane against Notts County.
The visitors found themselves behind to a Dean Leacock goal, but after Tommy Rowe's equaliser, Peterborough scored three goals in 17 second-half minutes to seal the points.
Tyrone Barnett, Grant McCann and record signing Britt Assombalonga got themselves on the scoresheet before Yoann Arquin grabbed a consolation for the hosts from the penalty spot.
Walsall and Colchester join them on six points after 1-0 wins over Oldham and Port Vale respectively.
Kenny Jackett got his first competitive win as Wolves manager as they cruised to a 4-0 victory over Gillingham.
Leigh Griffiths grabbed his first two goals for the club, with Lee Evans and Bakary Sako completing the comprehensive win.
The result leaves Gillingham still searching for their first point of the new season following promotion from League Two.
Martin Allen's side are joined by Stevenage, Carlisle United and Notts County searching for their first victory.
Elsewhere, there were victories for MK Dons over Crewe Alexandra and Brentford against Sheffield United, while Tranmere Rovers versus Crawley Town and Rotherham United against Preston North End both ended level.