Isco says that Real Madrid have a score to settle with Atletico Madrid after last year's lost Copa del Rey final defeat to Diego Simeone's side.
Los Blancos side host their local rivals at the Santiago Bernabeu on Wednesday evening for the first leg of their semi-final tie, their first meeting in the tournament following Los Rojiblancos' 2-1 defeat after extra time to win last season's trophy.
And the creative midfielder is hopeful that will emerge victorious this time around and make amends for missing out in 2012-13.
"It will be very difficult but we are very keen to get to the final and settle the unfinished business with Atletico after what happened last year," the 21-year-old told AS.
"It's going to be a wonderful cup tie but it's going to be very tight. We hope the semi-final with Atletico goes our way.
"We believe that right now we are in the best form we have shown this season. Now the biggest games of the season are coming up but we are prepared to take them on."
Madrid were beaten 1-0 by Atleti in La Liga earlier this season.