The two fierce rivals meet for the fourth time this season on Wednesday at the Santiago Bernabeu, before a return match at Camp Nou a week later. Who will prevail this time?
But now it's time for the Copa del Rey.
Last season, Barca had the better of the meetings with Madrid, winning 5-0 at Camp Nou in La Liga, claiming a win and a draw in the sides' Champions League semi-final tie and earning a point in the league at the Santiago Bernabeu.
The Copa del Rey, however, was the one exception.
Madrid beat Barca in a gripping final at Mestalla to claim their first silverware since 2007-08 and bragging rights over their fiercest foes - for a few days at least as the Catalans soon gained revenge by progressing in the teams' European tie and winning La Liga.
Now, Madrid are five points clear of Barca in the Primera Division and boast a healthy advantage going into the second half of the competition, but they were clearly second best as Pep Guardiola's side claimed a 3-1 victory at the Bernabeu on December 10.
So what will happen this time around? Have your say in the poll below and the results will be published before Wednesday's big game.