The club captain bids farewell to the Bianconeri on Sunday evening, and does so from the first whistle, while the Partenopei have their first-choice front line available
Del Piero, who was informed earlier in the season that his contract will not be renewed for 2012-13, has regularly been used as a substitute during Juve's successful Serie A campaign, but has often been promoted to the first XI for Coppa matches, and leads the team out for Sunday's final.
At the back, coach Antonio Conte brings in Martin Caceres in the absence of the injured Giorgio Chiellini, while Marco Storari is chosen to start in goal.
Napoli include all three of their attacking 'senators', with Marek Hamsik ahead of the midfield four, and Ezequiel Lavezzi joining Edinson Cavani up front.
The final kicks-off at 21.00CET at the Stadio Olimpico in Rome, with a near-capacity crowd anticipated. Juve will wear a commemorative shield on their shirts to mark Del Piero's final appearance for the club.
Bonucci, Caceres; Lichsteiner, Vidal, Pirlo, Marchisio, Estigarribia; Borriello, Del Piero.
Subs: Manninger, Padoin, Giaccherini, Pepe, Vucinic, Quagliarella, Matri.
Napoli (3-4-2-1): De Sanctis; Campagnaro, Cannavaro, Aronica; Maggio, Dzemaili, Inler, Zuniga; Hamsik; Lavezzi, Cavani.Juventus (3-5-2): Storari; Barzagli,
Subs: Rosati, Grava, Fernandez, Britos, Dossena, Pandev, Vargas.